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Up for sale a RARE! "Vitamin B6" Esmond Snell Hand Signed Album Page.
1914 – December 9, 2003) was an American biochemist who spent his career of bacteria and yeast.
He is well known for his study of lactic acid-producing bacteria, developing microbiological
assays for a number of key nutrients; the discovery of more than half
of known vitamins has been attributed to the use of this work. He discovered
several B vitamins, including folic acid, and characterized the biochemistry of vitamin B6 (also known as pyrixodal).
The fourth of five children, Snell was born in 1914 in Salt Lake City, Utah to
parents who met while serving as Mormon missionaries. The
family moved several times in Wyoming and Utah before settling in Provo, Utah so that the children could attend Brigham Young University.
Snell became interested in chemistry during high school and went on to study
chemistry at BYU; he also – "reluctantly", as he remembered later –
studied secondary education as "insurance" against the unemployment
of the Great Depression. After graduation, he received a scholarship to
continue his studies at the University of
Wisconsin–Madison, where he joined the research group of William
Harold Peterson and began his long career studying nutrition
and metabolism in microorganisms. Snell received his Ph.D. in
biochemistry in 1938 and moved to the University of Texas at
Austin, where he worked as a postdoctoral fellow with Roger J. Williams. Snell began his independent research career
with an appointment as an assistant professor of
chemistry at the University of Texas at Austin in 1941, advancing to associate
professor in 1943. He then moved back to his alma mater in 1945, joining the
biochemistry faculty of the University of Wisconsin and remaining there until
1951, when he returned to Austin to occupy newly constructed laboratory space.
In 1956 he was offered the chairmanship of the biochemistry department at
the University of California,
Berkeley, and relocated his laboratory there. He served as chair
until 1956 and remained in the department until 1976, departing briefly
for sabbatical visits to Feodor Lynen's research group in Munich, Germany and later to Osaka University in 1971. After 20 years at Berkeley,
Snell again returned to Austin for family reasons and became the chair of the
microbiology department there for the following four years. Snell became
the Ashbel Smith Professor
of Chemistry in 1980 and retired, assuming professor emeritus status,
in 1990. During his career Snell served on a number of scientific journal editorial
boards, most notably as the editor of the Annual Review of
Biochemistry from 1968 to 1983 and of Biochemical and Biophysical Research Communications from
1970 to 1985. Snell is widely recognized as one of the foremost nutritional
biochemists of the 20th century. His early work developing microbiological
assays for key nutrients has been credited with facilitating the discovery of
at least half of known vitamins due to their ease of use compared to more
traditional animal studies. His 1939 publication describing a
microbiological assay for riboflavin – then one of just two B vitamins known – is considered the first widely used
such assay. His notable discoveries using these methods include the
discovery and naming of folic acid, which Herschel K. Mitchell,
Snell, and Roger J. Williams isolated
from four tons of processed spinach and demonstrated to be
a growth factor for the
experimental organism Streptococcus faecalis. A
version of Snell's microbiological assay method based on the casei (now
known as Lactobacillus rhamnosus) is still used as a method for
detecting folates in blood. Snell's interest in isolating and characterizing
unknown nutrients and growth factors also led to the serendipitous discovery of
useful biochemical tools. While working to characterize the yeast growth factor
that would become known as biotin, Snell and coworkers discovered the
egg white protein avidin, which binds biotin with extremely
high affinity. At the time avidin was noted as a cause of "egg white
injury", a form of biotin deficiency in animals. The rarity and expense of obtaining biotin at
the time limited further investigations, but the extremely high avidin-biotin
binding affinity was later exploited and is now widely used in molecular biology for purification and molecular
detection applications. Snell is perhaps best known for his work
on vitamin B6; he and Soviet scientist Alexander E. Braunstein have
been cited as the "fathers of vitamin B6". Snell discovered two novel
forms of the substance – pyridoxal and pyridoxamine – and thus elaborated the underlying
biochemistry of enzymes that rely on In a series of experiments beginning in the 1940s and later
conducted with student David Metzler, a general mechanism for the catalytic cycle of
pyridoxal-dependent enzymes was discovered. Recalling his own work with
pyridoxal, French biophysicist Michel E. Goldberg described
Snell as "the pope of pyridoxal catalysis